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Symptom relief : Emerging data suggest they reduce hot flashes via neurotransmitter and blood sugar stabilization

Mean differences or ratios between treatment groups were estimated using a parametric linear mixed-effect model that included period and treatment group as fixed effects, and subject as a random effect

Despite promising Phase 2 results and an excellent safety profile, the compound could not demonstrate sufficient efficacy in the larger confirmatory trial to justify the investment required for continued pharmaceutical development toward regulatory approval

Semaglutide in SUSTAIN-6 trial reduced the risk of MACE by 26% in patients with T2D, mostly by reducing rate of nonfatal stroke (39%) compared to placebo