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Lin Y, Shen X, Ke Y, Lan C, Chen X, Liang B

As a major metabolic byproduct, ammonia plays multifaceted roles in the TME, influencing tumor progression, immune evasion, and therapeutic responses (89, 90)

p63 is a stem cell marker that belongs to a family that includes two structurally related proteins, p53 and p73 [16], while PCNA, which is present in proliferating cells throughout the cell cycle, is a well-established marker of proliferating cells [17]