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The overall program size was influenced by regulatory guidance to establish substantial evidence for an indication, including minimum patient exposures for a weight management indication, the desire to include participants with and without T2D, and conduct of at least two wellcontrolled trials for each indication (weight management, OSA and OA)

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IGF-I LR3 is a recombinant analog of human IGF-I comprised of the complete IGF-I sequence, with an Arginine substitution for the third position Glutamic acid, and a 13 amino acid length N terminus peptide extension