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Various studies on glutathione injection for dermatological use have proven that glutathione can alter the amount of melanin produced by the body.Also, it has been found that glutathione alters the ratio of eumelanin to pheomelanin and decreases the activity of tyrosinase (the enzyme responsible for producing melanin) both contributing to an eventual lessening of hyper pigmentation as well as unevenness of skin tones

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Since it is not yet approved, there is no official guidance for long-term dosing or real-world use