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Our findings suggest that GLP-1 receptor agonists, in particular, may have a protective effect on brain health. The findings, published in the journal JAMA Neurology, provide some of the best evidence to date that certain weight loss drugs may help to protect against Alzheimers disease

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This tachyphylaxis occurs with continuous infusion of GLP-1 (154, 157), long acting GLP-1RAs (156), or tirzepatide (151)

[24] [25] Weight management medications (including GLP-1 receptor agonists and orlistat) should generally be deferred until after weaning, unless exceptional circumstances warrant earlier intervention with careful risk-benefit assessment by specialists