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While we routinely perform lymphatic surgery for lymphedema, many patients are not candidates for surgery because of high BMI or do not want surgical intervention

The pharmacokinetics of saxagliptin and its active metabolite, 5-hydroxy saxagliptin were similar in healthy subjects and in patients with type 2 diabetes mellitus

We found that the full-length human GCLC transcript was cleaved by recombinant human IRE1 in vitro, which can be inhibited by 48c, a potent IRE1 RNase inhibitor 19 (Fig