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A Phase 2 trial (a mid-stage human trial, typically involving a few hundred participants) published in the New England Journal of Medicine in 2023 reported an average weight loss of about 24% at 48 weeks with the highest dose

And the lipid profile, total cholesterol and fractions and triglycerides were based on the normality values of the Brazilian Society of Cardiology, 2019-2020 ( 20 )