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Description

These targeted ER therapies are all currently experimental, although GPER1 agonists have recently entered clinical trials for the treatment of refractory solid organ malignancies where they appear to be well tolerated (NCT04130516)

Wild-type and mutated IDH1/2 enzymes and therapy responses

The current study represents the first systematic investigation of the pregnenolone sulfating activity of SULT2B1a allozymes, including their substrate affinity compared to the wild-type enzyme