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For many people, stopping a medication that has been helping regulate appetite can lead to increased hunger, cravings, and weight regain

Heart disease

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Receptor trafficking involves the internalisation of the active receptor: Ligand complex towards endocytic compartments, followed by its deactivation/dephosphorylation and recycling back to the cell membrane, leading to its re-sensitisation, or trafficking to lysosomal organelles for its degradation and final signal termination (McGlone et al., 2021)