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The peptide stimulates expression of early growth response 1 (EGR-1) gene, which regulates cytokine and growth factor generation along with early extracellular matrix formation, while simultaneously inducing its repressor NAB2 to prevent excessive angiogenic signaling

In this study, researchers discovered that a specific protein called FOXO4 is found in Leydig cells and its movement into the cell nucleus in older individuals is associated with reduced testosterone production