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Chem Res Toxicol 24:13451410

10.1007/s12035-018-1388-y Mol

In the later stages of pressure overload, administration of the mitochondrial-targeted superoxide dismutase (SOD) mimetic mitoTEMPO can partially restore mitochondrial respiration and cardiac contractility by partially restoring LONP1 activity, but in vivo knockdown of LONP1 can partially counteract this protective effect [67]