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Collagen XI alpha 1 Polyclonal Antibody, 100ul Cryogenic Vials The encoded preproprotein is proteolytically

SKU: 14720917451

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Collagen XI alpha 1 Polyclonal Antibody, 100ul Cryogenic Vials The encoded preproprotein is proteolyticallyThis gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants

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Description

The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase

probably through an TIR-TIR domain interaction with TLR4

Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis

subunit:Interacts with CSK/c-Src

Collagen XI alpha 1 Polyclonal Antibody, 100ul Cryogenic Vials The encoded preproprotein is proteolyticallyThis gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants

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