GFAP(Phospho Ser38) Polyclonal Antibody, 20ul Pipette Controller Mutations in this gene have

Mutations in this gene have been associated with chronic granulomatous disease

It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements

A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient

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GFAP(Phospho Ser38) Polyclonal Antibody, 20ul Pipette Controller Mutations in this gene haveThis gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.