ERCC2 Polyclonal Antibody, 100ul Cryopreservation an MAPKK that activates ERKs

an MAPKK that activates ERKs

Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes

2007 [PubMed: 17499941])

this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer

ERCC2 Polyclonal Antibody, 100ul Cryopreservation an MAPKK that activates ERKsThe nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2 TFIIH complex. The gene product has ATP dependent DNA helicase activity and belongs to the RAD3 XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer prone syndrome