BMPER Polyclonal Antibody, 20ul Molecular Sciences Mutations in NOTCH4 may be

Mutations in NOTCH4 may be associated with schizophrenia

suggesting that reticulon proteins are negative modulators of BACE1 in cells

Decreased expression of this gene is associated with splenic marginal zone lymphomas

Detected in small intestine

BMPER Polyclonal Antibody, 20ul Molecular Sciences Mutations in NOTCH4 may beThis gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2 and BMP4 dependent osteoblast differentiation and BMP dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis.