SLP-76(Phospho Tyr128) Polyclonal Antibody, 20ul Immune Cell Analysis The N-terminal region of the

The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity

subunit:Interacts (via SH3 domain) with focal adhesion kinase (via C-terminus)

Mutations in PEX2 result in one form of Zellweger syndrome and infantile Refsum disease

This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum

SLP-76(Phospho Tyr128) Polyclonal Antibody, 20ul Immune Cell Analysis The N-terminal region of theSLP 76 was originally identified as a substrate of the ZAP 70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP 76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2 terminus contains an acidic