Raf-1(Phospho Ser642) Polyclonal Antibody, 20ul Organelle Studies • 2kg and speed range

• 2kg and speed range 10-80rpm

This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes| platelet dense granules| and lysosomes

In mice| expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis

This kinase has been shown to directly phosphorylate and activate Ikappa B kinases| and thus plays a role in NF-kappa B signaling pathway

Raf-1(Phospho Ser642) Polyclonal Antibody, 20ul Organelle Studies • 2kg and speed rangeThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.