SPB8 Polyclonal Antibody, 100ul Deep Well Plates Defects in this gene results

Defects in this gene results in hemophilia A

This protein and ATM share similarity with Schizosaccharomyces pombe rad3| a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage

Homotetramers consisting of a proteolytically cleaved form of the protein| or type A subunit| exhibit low affinity for heparin and do not interact with the ECM

but not for neutrophils

SPB8 Polyclonal Antibody, 100ul Deep Well Plates Defects in this gene resultsThe superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989