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331 Although reductions in systolic and diastolic blood pressure were observed in the treatment groups, these changes did not reach statistical significance, possibly due to the limited sample size and study power

Deyno S, Eneyew K, Seyfe S, et al

These inconsistencies may be attributed to methodological differences such as variations in cognitive assessment tools, particularly the sensitivity of longitudinal applications of MoCA and MMSE vs

Clinical Evidence for Tirzepatide in Non-Diabetic Patients The STEP trials, which tested semaglutide (a related GLP-1 drug), enrolled thousands of non-diabetic overweight and obese adults and showed average weight reductions of 15-22% over 68 weeks