VH 298 20046 MLN2238 (7 mg/kg) shows greater
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VH 298 20046 MLN2238 (7 mg/kg) shows greaterVH 298 is a potent VHL inhibitor that stabilizes HIF and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL: HIF protein protein interaction downstream of HIF hydroxylation by PHD enzymes. VH298 represents a high quality chemical probe of the HIF signalling cascade and an attractive starting point to the development of potential new therapeutics targeting hypoxia signalling. Product information CAS Number: 2097381 85
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