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Afamelanotide is FDA-approved for EPP at 16 mg subcutaneous implant every 60 days roughly 2 mg/day of continuous release (Langendonk et al., 2015)

But some compounding pharmacies are now trying to continue this practice after a drug shortage endsskirting FDA safety regulations and oversight, and potentially jeopardizing patient health. Compounding pharmacies lower regulatory compliance costs can contribute to a lower price point, which is frequently emphasized in direct-to-consumer advertising such as a recent Super Bowl ad for compounded GLP-1s watched by 123 million people

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Exp Mol Med (2023) 55(4):70615