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As detailed in this review, through well-established top-down or bottom-up strategies, various metal nanozymes have been successfully integrated into hydrogel networks, achieving multifunctional synergy

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Chondrocyte dedifferentiation was majorly characterized as the reduced expression of COL2 and ACAN and enhanced expression of type I collagen and versican ( COL2 expression, but not ACAN ( In addition to dedifferentiation, another consequence of in vitro expansion is replicative senescence, which also significantly influences chondrocyte function