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101 Phosphorylation of fumarate hydratase (FH) by p38 in response to TGF- signaling leads to its binding to the transcription factor CSL/p53 complex on the p21 promoter, which inhibits histone H3K36 demethylation, enhances p21 transcription, and induces cell growth arrest

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Glomerular and tubular functions in children and adults with transfusion-dependent thalassemia

[0024] In the present invention, Fmoc-Lys(Alloc)-OH is used as a raw material, which simplifies the deprotection step, and eliminates the side reactions brought out during the deprotection of Mmt and Mtt, and the operation safety risk in removing Dde or ivDde protecting groups in the scale-up process