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Individualized targets: Glycemic targets should be individualized to balance efficacy and safety, particularly in patients with advanced disease or multiple comorbidities

If disease activity remains inadequately controlled, treatment should escalate to combination conventional synthetic DMARDs or biological agents following a treat-to-target approach

Despite these advances, the mechanisms underlying the metabolic benefits of GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists remain poorly understood

NK cells eliminate tumor cells by releasing cytotoxic granules containing granzyme B, and among the immunosuppressive mechanisms associated to NK cells, secreted galectin-1 hinders the tumor-killing effects of these cells by reducing the release of granzyme B [49, 50]