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The pathophysiology involves dysregulated immune responses, genetic susceptibility, environmental triggers, and alterations in the gut microbiome

Individuals of childbearing potential with obesity being considered for obesity medication should be counseled on contraception options and the impact of some obesity medications on contraception efficacy

Notably, symptom improvements in prebiotic-treated males persisted at weeks 2 and 12, contrasting with transient effects in placebo-treated males (Voigt et al., 2025)