SW033291 - 15-PGDH Inhibitor. CAS# 459147-39-8 Catalog No.:M60298-10S Targeting of HIF-alpha to the
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SW033291 - 15-PGDH Inhibitor. CAS# 459147-39-8 Catalog No.:M60298-10S Targeting of HIF-alpha to theSW033291, CAS No. 459147 39 8, is a highly potent and selective inhibitor of 15 PGDH enzyme with IC50 1. 5 nM, can increase prostaglandin PGE2 levels in bone marrow and other tissues. It inhibits 15 PGDH with noncompetitive pattern. Treatment of A549 cells with SW033291 increased PGE2 levels by 3. 5 fold at 500 nM, with EC50 value of ~75 nM. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. It also promotes tissue
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