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The New England Journal of Medicine , 384 (11), 989-1002

Many clinical trials have reported gastrointestinal side effects as among the most common side effects of GLP-1 receptor agonists, contributing to decreased fluid intake

Cardiovascular diabetology

I can tell you about the patients that I helped lose 50 pounds, that I helped lose 100 pounds, and they still look in the mirror and are not happy. The key is seeking help for mental health along the way, said Gerald Onuoha, who practices internal medicine in Nashville, Tennessee